Loop diuretics, such as the active ingredient furosemide, can wash essential vitamins and minerals out of the body due to increased urinary excretion. In particular, vitamins B1, B6, B12 and folic acid, as well as the minerals magnesium and calcium are excreted in increased quantities. This can result in a deficiency of the vitamins and minerals with corresponding deficiency symptoms
. The homocysteine level may also rise as a consequence of a deficit of B vitamins. Homocysteine is a toxic intermediate metabolic product which damages the blood vessels and increases the risk of cardiovascular disease.
Magnesium deficiencies also put a significant strain on the heart and circulation: the blood pressure may rise and the heart lose its normal rhythm.
If a vitamin B1 deficiency become acute, it can result in nerve damage and even cause or exacerbate cardiac insufficiency (heart failure). What can be done?
Deficiency symptoms or (in case of doubt) a blood test (background information on the blood analysis
) may indicate an under-supply of the stated biofactors.
If a deficiency is confirmed you should make sure that you supplement the corresponding biofactors by means of the appropriate preparations.
In the case of a deficiency of folic acid, vitamin B6 or vitamin B12, as well as raised homocysteine levels, supplementation with a combination of the three vitamins folic acid, B6 and B12 is advisable, as the three vitamins work closely together and lower the homocysteine level in combination.
For those who are at risk of cardiovascular diseases, such as high blood pressure patients or diabetics with magnesium deficiency, preparations from the pharmacy containing the compound magnesium orotate are an advantage, as the biofactor orotate promotes the intracellular binding of the magnesium. In this way it is possible to quickly compensate for magnesium losses in the (cardiac) cells caused by stress and other negative influences. A vitamin B1 deficiency is effectively compensated for orally by a fat-soluble precursor of vitamin B1 (benfotiamine). The reason for this is that conventional vitamin B1 can only pass into the blood (be absorbed) in limited quantities in the intestine. The vitamin precursor benfotiamine, on the other hand, passes into the body in much larger quantities. Diabetics in particular are advised to take benfotiamine, as diabetes also causes significant losses of vitamin B1 in some cases, which in turn promote diabetic nerve damage. In addition, you should of course also make sure that you have a healthy and balanced diet and get plenty of regular exercise.