Warning – high blood pressure: What role does magnesium play?

On the occasion of World Hypertension Day on May 17, 2020, experts from the German Society for Biofactors (GfB) point out the blood pressure-lowering effect of magnesium.

Magnesium deficiency: Risk factor for heart and blood vessels
The number of hypertension patients worldwide has increased alarmingly in recent years. In Germany, more than half of the people in the 60 and over age group suffer from high blood pressure – with fatal consequences for the heart and brain. This is because high blood pressure increases the risk of heart disease and strokes.
Diuretics are considered the standard method of treating high blood pressure. They remove water from the body and in this way reduce the pressure in the blood vessels. However, important minerals – especially magnesium – are also lost with the fluid. A vicious circle, as magnesium not only helps against the wellknown nocturnal calf cramps1, but also plays an important role in the performance of the heart muscle. As a natural calcium antagonist, magnesium dilates the blood vessels and lowers the blood pressure, as well as being able to normalise the heart rate and protect heart muscle tissue.2 Conversely, a magnesium deficiency can promote neuromuscular excitability, which increases the risk of high blood pressure, cardiac insufficiency and arrhythmias.3,4

When patients suffer from high blood pressure
"Numerous studies show that magnesium substitution has a positive influence on high blood pressure.5 The investigations prove that there is a lowering effect on both systolic and diastolic blood pressure," emphasised also Prof. Dr. med. Klaus Kisters, Chief Physician of Medical Clinic I at St. Anna Hospital in Herne and one of the scientific experts of the German Society for Biofactors (GfB) in this context.

Positive effect of magnesium therapy on high blood pressure and cardiac insufficiency
When supplementing with magnesium, it should be borne in mind that organic compounds are better tolerated than inorganic compounds as a rule and are characterised by higher bioavailability.6,7 "Scientific investigations8 prove that the quality of life and life expectancy increase in patients with heart disease resulting from high blood pressure and heart failure when they receive oral therapy with magnesium orotate, "explains the medical expert Prof. Kisters.
Magnesium deficiency in hypertension should therefore be avoided without fail in order to minimise further consequential damage and a reduction in the patient's quality of life – this is the clear statement of the scientists from the German Society for Biofactors.


  1. Roffe C et al.: Randomised cross-over placebo-controlled trial of magnesium citrate in the treatment of chronic persistent leg cramps. Med Sci Monit 2002; 8(5)
  2. Tangvoraphonkchai K: Magnesium and cardiovascular disease. Adv Chronic Kidney Dis 2018, May; 25(3): 251-260
  3. Zhang X, Li Y, Del Gobbo LC et al.: Effects of magnesium supplementation on blood pressure. A meta-analysis of randomized double-blind placebo-controlled trials. Hypertension 2016
  4. Wannamethee SG et al.: Serum magnesium and risk of incident heart failure in older men: The British Regional Heart Study. Eur J Epidemiol 2018, 33(9): 873-8824
  5. Kisters K et al.: Wirkung von Magnesium bei Hypertonie. (Effect of magnesium in hypertension.) Zeitschrift für orthomolekulare Medizin 2006; 2: 12-15
  6. Walker AF et al.: Mg citrate found more bioavailable than other Mg preparations in a randomised, double-blind study. Magnes Res 2003 Sep, 16(3): 183-91
  7. Kisters K et al: Magnesiumhaushalt und –therapie bei Hypertonie (Magnesium balance and therapy for hyper-tension). Nieren- und Hochdruckerkrankungen 2020; 49(5): 245-251
  8. Kisters K et al.: Positive effect of magnesiumorotate therapy in hypertensive heart disease. Metabolomics: Open Access. 2017; 7: 3